Toxicity attenuation of atractyloside in traditional chinese medicinal herbs after hydrothermal processing
نویسندگان
چکیده
Atractyloside (ATR) is a diterpenoid glycoside and occurs naturally in Asteraceae plants, many of which are used in foods and ethnomedicines. The toxicity of ATR has caused fatal renal proximal tubule necrosis and/or centrilobular hepatic necrosis in man and farm animals. A GC/MS screening method was optimized to detect the presence of ATR in Atractylodes species which are important herbs used in traditional Chinese medicine. The stability and hydrothermal detoxification of ATR in practical processing were also evaluated quantitatively by chromatographic analysis. In addition, the effects of hydrothermal detoxification of ATR from different processing methods on cell viability were performed. The results suggest that degradation of ATR is a way to increase pharmaceutical safety for the Chinese medicinal industries.
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